Family nurses are well-positioned to use advances in genomics to promote family strengths. However, many family nurses feel unprepared to fully incorporate these advances into their teaching, research and practice. The goal of this expert lecture is to provide practical tips and strategies for how family nurses can confidently use advances in genomics to promote family strengths by fostering a shared understanding about genetic conditions and genetic risk, empowering families to make well-informed decisions, enhancing family communication about decision-making regarding genetic testing and treatment options, and assessing the impact of being tested for and living with a genetic condition.